Creatine Monohydrate (Thorne)
Serving size: 1 Scoop
Servings per container: 90

450 Grams/Containers (16oz)

Creatine is one of the largest consumers of methylation activity, accounting for more than 50% of the body’s methylation demand. This makes it a critical factor in maintaining methylation balance, particularly for individuals with high metabolic needs, neurological conditions, or genetic undermethylation.

Who Needs More Creatine?

• High Muscle Demand: Athletes, bodybuilders, and those with physically demanding lifestyles require more creatine for muscle energy and recovery.
• Neurological Conditions: Creatine supports brain energy metabolism, making it beneficial for neurodegenerative disorders, cognitive decline, and conditions like depression.
• Genetic Undermethylators: Individuals with high histamine, low SAMe, or MTHFR mutations may have impaired methylation efficiency, leading to suboptimal creatine synthesis.
• Vegetarians & Vegans: Since creatine is primarily found in animal products, those on plant-based diets may have lower creatine stores and require supplementation.
• Aging Population: Natural creatine production declines with age, reducing energy levels and muscle retention.

Physiological Functions of Creatine

• Supports Methylation Efficiency: By supplementing with creatine, the body reduces the demand for endogenous synthesis, freeing up methyl donors (SAMe) for other essential processes like neurotransmitter production and DNA repair.
• Enhances ATP Production: Creatine stores phosphate groups, rapidly regenerating ATP (cellular energy), which is crucial for muscle contraction, brain function, and overall metabolism.
• Neuroprotection & Cognitive Support: Plays a key role in brain energy metabolism, reducing oxidative stress, stabilizing mood, and supporting cognitive function.
• Muscle Growth & Recovery: Improves muscle strength, endurance, and repair, making it essential for athletes and those recovering from illness or injury.
• Regulates Homocysteine Levels: Since excess methylation demand can contribute to elevated homocysteine, creatine supplementation may help reduce strain on the methylation cycle, supporting cardiovascular and metabolic health.

Creatine in the Epstein Protocol for Undermethylators

Dr. Epstein recommends creatine supplementation for individuals with undermethylation tendencies as part of a targeted nutrient therapy approach. By reducing the body’s methylation burden, creatine helps optimize neurotransmitter balance, improve cognitive function, and enhance physical energy levels, making it a cornerstone supplement for long-term health and performance.

These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.